Olympique Lyon vs Crystal Palace Prediction, Betting Tips & Preview

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🏟️ Groupama Stadium, Décines-Charpieu
Odds: 1.66
Lyon Draw No Bet
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Key Facts
✓ Lyon have conceded only four goals in six Ligue 1 games
✓ Lyon are unbeaten in 12 home games in the group or league phase of European competitions
✓ Palace are without Jean-Philippe Mateta and Dean Henderson
✓ Pierre Sage returns to the club that sacked him in January 2025

Pierre Sage returns to Lyon with an injury-hit Palace

Crystal Palace travel to the Groupama Stadium to face Olympique Lyon on Thursday, 15 October 2026, in the second round of the Europa League league phase. Both sides won on matchday one, Lyon 2-1 at Anderlecht and Palace 4-0 at home to Lech Poznań. The story of the night is in the away dugout: Palace manager Pierre Sage coached Lyon from November 2023 to January 2025 and now returns as the opposition. Kick-off is at 18:45.

“Nous avons sorti le club de l’ornière et lui nous a sorti de l’anonymat.” – Crystal Palace manager Pierre Sage on his time at Lyon

Predicted lineups: Lyon vs Palace

Both sides are without their first-choice striker. Lyon have lost Loïs Openda for several weeks with a fibula injury, and Moussa Niakhaté (hamstring) and Mohamed Ouédraogo (knee) are also out, so Pavel Šulc could lead the line. Keito Nakamura, who scored in Anderlecht, is pushing for a recall. Palace are missing Jean-Philippe Mateta (hamstring), captain and goalkeeper Dean Henderson (foot) and Chadi Riad (knee), while Takehiro Tomiyasu is a doubt. Walter Benítez continues in goal and Jørgen Strand Larsen leads the attack.

Olympique Lyon 4-2-3-1
Greif
Athekame
Mata
Kluivert
Abner
Bidstrup
Morton
Nuamah
Tolisso
Nakamura
Šulc
Absences
Opendafibula
Niakhatéhamstring
Ouédraogoknee
Crystal Palace 3-4-3
Benítez
Ahanor
Disasi
Richards
Khalaili
Timber
Wharton
Mitchell
Kamada
Strand Larsen
Pino
Absences
Matetahamstring
Hendersonfoot
Riadknee
Tomiyasucalf

Olympique Lyon Team News & Preview

Lyon are fourth in Ligue 1 with 11 points from six games and have the joint-best defence in the division, with four goals conceded. Last Friday’s 2-1 defeat at Lens ended a five-game unbeaten run, but before that Paulo Fonseca’s side had beaten Rennes 4-0, with Ernest Nuamah scoring twice.

The European home record is the main reason I like Lyon here. They are unbeaten in 12 home games in the group or league phase of European competitions, with seven wins and five draws since December 2018. They also had six days to prepare after the Lens game, compared with four for Palace.

What works for or against Lyon

  • Only four goals conceded in six league games.
  • Unbeaten in 12 home games in European group or league phases.
  • Without Openda and Niakhaté.
  • Lost 2-1 at Lens on Friday, their first defeat in six.

Crystal Palace Team News & Preview

Palace are 12th in the Premier League with seven points from six games and a goal difference of minus three. Sunday’s 3-1 win over Nottingham Forest was their first home league win under Sage, but it was not a dominant one: Forest led after three minutes and hit the bar before Kamada equalised just before half-time, Lerma headed in from a corner in stoppage time and Pino added a third after the break.

The away form is a concern. Palace have won only one of their last eight away games in all competitions, and three of their last four competitive matches produced at least four goals. Without Mateta and Henderson, they also lose their main goal threat and their captain.

What works for or against Palace

  • Came from behind to beat Forest 3-1 on Sunday.
  • Won 4-0 against Lech on matchday one.
  • One win in their last eight away games.
  • Mateta, Henderson and Riad all out.

Lyon vs Palace Odds

Lyon vs. C. Palace Stats Comparison

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Lyon vs. C. Palace Form Guide

Lyon C. Palace
Recent Matches
Lyon
W-D-L: –
Recent Matches
C. Palace
W-D-L: –

Lyon Form, Stats & Data

Lyon Team Check
Squad Value –
FotMob Rating –
xG –
xGA –
League Position 4.
Form
Goals / Match 1.83
Goals Against / Match 0.67
Goal Difference 11:4
Possession –
Shots / Match –
Aufs Tor / Spiel –
Manager Paulo Fonseca
Most Valuable Player –
Top Scorer Nuamah – 3 goals
Top-Rated Player –
Outlook

Lyon concede 0.67 goals per league game, and their back line has coped well even with rotation. The question is up front, where Openda’s absence leaves Šulc, Nakamura and Nuamah to share the goals. At home in Europe, they have been very hard to beat for the best part of eight years.

C. Palace Form, Stats & Data

C. Palace Team Check
Squad Value –
FotMob Rating –
xG –
xGA –
League Position 12.
Form
Goals / Match 1.50
Goals Against / Match 2.00
Goal Difference 9:12
Possession –
Shots / Match –
Aufs Tor / Spiel –
Manager Pierre Sage
Most Valuable Player –
Top Scorer Mitchell – 2 goals
Top-Rated Player –
Outlook

Palace concede two goals per league game and have often been second best in first halves. Their top league scorer is left wing-back Tyrick Mitchell with two, which shows how much they will miss Mateta. Sage knows Lyon well, but this squad has not travelled well this season.

Lyon vs Palace: Prediction & Betting Tip

Lyon have the better defence, the longer rest and an excellent European home record, while Palace arrive without their captain, their goalkeeper and their main striker, and with one win in eight away from home. I make Lyon the right side, and Draw No Bet gives me protection if Sage’s knowledge of his old club helps Palace to a point.

The biggest risk is Palace’s European pedigree. They have lost only one of their last 12 European games, and they beat Lech 4-0 on matchday one. Lyon are also without Openda, so they may struggle to turn control into goals. But Palace’s away form and their injury list tip it towards the hosts for me.

Lyon Draw No Bet at 1.66 with Winz is the bet. Correct score: 2-1.

Alternative Betting Tips for Lyon vs Palace

Alternative Bet
Odds: 3.25
Ernest Nuamah to score anytime
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Key Facts
✓ Nuamah is Lyon's top league scorer with three goals, two of them in the 4-0 win over Rennes.

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